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Article

The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2014

Li Fu, Yi Long, Zhao Lei, Itzen Aymelt, Goody Roger S, Wu Yao-Wen

Abstract excerpt

Intracellular membrane trafficking requires correct and specific localization of Rab GTPases. The hypervariable C-terminal domain (HVD) of Rabs is posttranslationally modified by isoprenyl moieties that enable membrane association. A model asserting HVD-directed targeting has been contested in previous studies, but the role of the Rab HVD and the mechanism of Rab membrane targeting remain elusive. To elucidate...

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Identifiers

PMID: 24550285
DOI: 10.1073/pnas.1313655111
PMCID: PMC3932868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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