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Article

Dual prenylation is required for Rab protein localization and function.

Molecular biology of the cell - 1 May 2003

Calero Monica, Chen Catherine Z, Zhu Wenyan, Winand Nena, Havas Karyn A, Gilbert Penny M, Burd Christopher G, Collins Ruth N

Abstract excerpt

The majority of Rab proteins are posttranslationally modified with two geranylgeranyl lipid moieties that enable their stable association with membranes. In this study, we present evidence to demonstrate that there is a specific lipid requirement for Rab protein localization and function. Substitution of different prenyl anchors on Rab GTPases does not lead to correct function. In the case of YPT1 and SEC4, two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12802060
DOI: 10.1091/mbc.e02-11-0707
PMCID: PMC165082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dual prenylation is required for Rab protein localization and function.PMID 12802060Read ↗

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