Article
Association of Rab1B with GDP-dissociation inhibitor (GDI) is required for recycling but not initial membrane targeting of the Rab protein.
The Journal of biological chemistry - 3 May 1996
Wilson A L, Erdman R A, Maltese W A
Abstract excerpt
We have identified the Rab1B effector-domain mutant (D44N) that, when geranylgeranylated by Rab:geranylgeranyltransferase (GGTase II) in cell-free systems or intact cells, fails to form detectable complexes with GDP-dissociation inhibitors (GDIs). GDI-Rab complexes were collected on anti-FLAG aff...
Topics
- Amino Acid Sequence
- Biological Transport
- Cell Compartmentation
- Cell Line
- Cell Membrane
- Endoplasmic Reticulum
- GTP-Binding Proteins
- Golgi Apparatus
- Guanine Nucleotide Dissociation Inhibitors
- Humans
- Molecular Sequence Data
- Mutation
- Subcellular Fractions
- rab1 GTP-Binding Proteins