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Article

Ribosomes stalling on uORF1 in the Xenopus Cx41 5' UTR inhibit downstream translation initiation.

Nucleic acids research - 15 Jun 2003

Meijer Hedda A, Thomas Adri A M

Abstract excerpt

Translation of Xenopus laevis Connexin41 mRNA is strongly controlled by the three upstream open reading frames (uORFs) in its 5' untranslated region. Mutation of uAUG1 into AAG induced a 100-fold increase in translation of a green fluorescent protein (GFP) reporter ORF. The termination codon of uORF1 was mutated and the uORF was linked in-frame with the GFP ORF, enabling visualisation of initiation at uAUG1 by...

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Identifiers

PMID: 12799445
DOI: 10.1093/nar/gkg429
PMCID: PMC162333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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