Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Capped mRNA with a Single Nucleotide Leader Is Optimally Translated in a Primitive Eukaryote, Giardia lamblia

1 Apr 2004

Abstract excerpt

The 5'-untranslated region (5'-UTR) of an mRNA plays an important role in translation initiation in eukaryotes. A minimal length of about 20 nucleotides is required to prevent leaky ribosome scanning. In one of the most primitive eukaryotes, Giardia lamblia, however, the mRNAs have 5'-UTRs mostly in the range of 0 to 14 nucleotides without a conserved sequence, which raises the question on how the ribosome could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasitic Infections and Diagnostics
Share to RNA and protein synthesis mechanisms
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14722094
DOI: 10.1074/jbc.m309879200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Capped mRNA with a Single Nucleotide Leader Is Optimally Translated in a Primitive Eukaryote, Giardia lambliaPMID 14722094Read ↗

Identification of a novel internal ribosome entry site in giardiavirus that extends to both sides of the initiation codon.Semantic proximity Read ↗

The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiationSemantic proximity Read ↗

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read ↗

Reversal of G-Quadruplexes’ Role in Translation Control When Present in the Context of an IRESSemantic proximity Read ↗

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiationSemantic proximity Read ↗

Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs.Semantic proximity Read ↗

40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion.Semantic proximity Read ↗

Translation initiation mediated by RNA loopingSemantic proximity Read ↗

A 43-Nucleotide U-rich Element in 3′-Untranslated Region of Large Number of Trypanosoma cruzi Transcripts Is Important for mRNA Abundance in Intracellular AmastigotesSemantic proximity Read ↗

Distance-dependent inhibition of translation initiation by downstream out-of-frame AUGs is consistent with a Brownian ratchet process of ribosome scanningSemantic proximity Read ↗

Identification in the ancient protist Giardia lamblia of two eukaryotic translation initiation factor 4E homologues with distinctive functions.Semantic proximity Read ↗

Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.