Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers.

doi:10.1093/genetics/164.3.1175

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Article

Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers.

Genetics - 1 Jul 2003

Cheng Rong, Ma Jennie Z, Wright Fred A, Lin Shili, Gao Xin, Wang Daolong, Elston Robert C, Li Ming D

Abstract excerpt

As the speed and efficiency of genotyping single-nucleotide polymorphisms (SNPs) increase, using the SNP map, it becomes possible to evaluate the extent to which a common haplotype contributes to the risk of disease. In this study we propose a new procedure for mapping functional sites or regions...

Topics

Algorithms
Chromosome Mapping
Computer Simulation
Family
Haplotypes
Linkage Disequilibrium
Models, Genetic
Polymorphism, Single Nucleotide

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