Article
Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers.
Genetics - 1 Jul 2003
Cheng Rong, Ma Jennie Z, Wright Fred A, Lin Shili, Gao Xin, Wang Daolong, Elston Robert C, Li Ming D
Abstract excerpt
As the speed and efficiency of genotyping single-nucleotide polymorphisms (SNPs) increase, using the SNP map, it becomes possible to evaluate the extent to which a common haplotype contributes to the risk of disease. In this study we propose a new procedure for mapping functional sites or regions of a candidate gene of interest using multiple linked SNPs. Based on a case-parent trio family design, we use...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.