Article
A tool for selecting SNPs for association studies based on observed linkage disequilibrium patterns.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2006
De La Vega Francisco M, Isaac Hadar I, Scafe Charles R
Abstract excerpt
The design of genetic association studies using single-nucleotide polymorphisms (SNPs) requires the selection of subsets of the variants providing high statistical power at a reasonable cost. SNPs must be selected to maximize the probability that a causative mutation is in linkage disequilibrium (LD) with at least one marker genotyped in the study. The HapMap project performed a genome-wide survey of genetic...
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