Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome.

Neuroreport - 6 May 1997

Farrer M J, Crayton L, Davies G E, Oliver C, Powell J, Holland A J, Kessling A M

Abstract excerpt

Genetic variation in the APOE gene and variation in chromosome 21 genotypes, including the APP locus, may influence age-associated cognitive decline in adults with Down syndrome. Molecular genetic and longitudinal neuropsychological analysis was performed for 41 unrelated Caucasian individuals (m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Alleles
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Chromosomes, Human, Pair 21

Share to APOE gene

Share to APP gene

Share to Genotype

Source

Identifiers

PMID: 9189907
DOI: 10.1097/00001756-199705060-00018

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9189907-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome.PMID 9189907Read ↗

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read ↗

Aging and Alzheimer's disease in Down syndrome: Clinical and pathological changesSemantic proximity Read ↗

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.Semantic proximity Read ↗

Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?Semantic proximity Read ↗

ApoE genotype and Alzheimer's disease in adults with Down syndrome: meta-analysis.Semantic proximity Read ↗

Molecular mapping of alzheimer‐type dementia in Down's syndromeSemantic proximity Read ↗

APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome.Semantic proximity Read ↗

Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP.Semantic proximity Read ↗

Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia.Semantic proximity Read ↗

Down syndrome and Alzheimer's disease: A link between development and agingSemantic proximity Read ↗

Cognitive Changes associated with Alzheimer’s disease in Down syndromeSemantic proximity Read ↗

Behavioral phenotype of individuals with Down syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.