Article
The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians.
Prion - 1 Jan 2000
Golanska Ewa, Sieruta Monika, Corder Elizabeth, Gresner Sylwia M, Pfeffer Anna, Chodakowska-Zebrowska Malgorzata, Sobow Tomasz M, Klich Izabela, Mossakowska Malgorzata, Szybinska Aleksandra, Barcikowska Maria, Liberski Pawel P
Abstract excerpt
The PRNP gene encodes the cellular isoform of prion protein (PrP (c) ). The M129V polymorphism influences the risk of prion diseases and may modulate the rate of neurodegeneration with age. We present the first study of the polymorphism among Polish centenarians. In the control group (n = 165, ages 18 to 56 years) the observed M129V genotype frequencies agreed with those expected according to the Hardy-Weinberg...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.