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Article

Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis.

Neurobiology of aging - 1 May 2006

Del Bo Roberto, Scarlato Marina, Ghezzi Serena, Martinelli-Boneschi Filippo, Fenoglio Chiara, Galimberti Gloria, Galbiati Sara, Virgilio Roberta, Galimberti Daniela, Ferrarese Carlo, Scarpini Elio, Bresolin Nereo, Comi Giacomo Pietro

Abstract excerpt

The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this issue, we performed a novel case-control study and a meta-analysis of published association...

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Identifiers

PMID: 16099550
DOI: 10.1016/j.neurobiolaging.2005.05.025

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis.PMID 16099550Read ↗

[The relationship between prion protein gene codon 129 polymorphism and Alzheimer's disease].Semantic proximity Read ↗

PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.Semantic proximity Read ↗

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease.Semantic proximity Read ↗

A novel mutation I215V in the PRNP gene associated with Creutzfeldt-Jakob and Alzheimer's diseases in three patients with divergent clinical phenotypes.Semantic proximity Read ↗

The First Meta-Analysis of the M129V Single-Nucleotide Polymorphism (SNP) of the Prion Protein Gene (PRNP) with Sporadic Creutzfeldt-Jakob Disease.Semantic proximity Read ↗

The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians.Semantic proximity Read ↗

The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of Alzheimer disease: an update by meta-analysis.Semantic proximity Read ↗

Prion protein gene M129 allele is a risk factor for Alzheimer's disease.Semantic proximity Read ↗

Prion protein codon 129 polymorphism and risk of Alzheimer disease.Semantic proximity Read ↗

The influence of PRNP polymorphisms on human prion disease susceptibility: an update.Semantic proximity Read ↗

Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt-Jakob Disease phenotype.Semantic proximity Read ↗

Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene.Semantic proximity Read ↗

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