Article
Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor.
Genesis (New York, N.Y. : 2000) - 1 Feb 2009
Lee Tang-Cheng, Threadgill David W
Abstract excerpt
The epidermal growth factor receptor (EGFR) is important for normal homeostasis in a variety of tissues and, when abnormally expressed or mutated, contributes to the development of many diseases. However, in vivo functional studies are hindered by the lack of adult mice lacking EGFR because of the pre- and postnatal lethality of EGFR deficient mice. We generated a conditional allele of Egfr (Egfr(tm1Dwt)) by...
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