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Article

YAP‐TEAD signaling promotes basal cell carcinoma development via a c‐JUN/AP1 axis

23 Jul 2018

Abstract excerpt

The mammalian Hippo signaling pathway, through its effectors YAP and TAZ, coerces epithelial progenitor cell expansion for appropriate tissue development or regeneration upon damage. Its ability to drive rapid tissue growth explains why many oncogenic events frequently exploit this pathway to promote cancer phenotypes. Indeed, several tumor types including basal cell carcinoma (BCC) show genetic aberrations in...

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PMID: 30037824
DOI: 10.15252/embj.201798642

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