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Article

Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants.

The EMBO journal - 15 Dec 1997

Zeitlinger J, Kockel L, Peverali F A, Jackson D B, Mlodzik M, Bohmann D

Abstract excerpt

Drosophila kayak mutant embryos exhibit defects in dorsal closure, a morphogenetic cell sheet movement during embryogenesis. Here we show that kayak encodes D-Fos, the Drosophila homologue of the mammalian proto-oncogene product, c-Fos. D-Fos is shown to act in a similar manner to Drosophila Jun: in the cells of the leading edge it is required for the expression of the TGFbeta-like Decapentaplegic (Dpp) protein,...

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Identifiers

PMID: 9405368
DOI: 10.1093/emboj/16.24.7393
PMCID: PMC1170339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants.PMID 9405368Read ↗

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Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.Semantic proximity Read ↗

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