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Article

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis.

Molecular and cellular biology - 1 Sept 2004

Kudo Yasusei, Guardavaccaro Daniele, Santamaria Patricia G, Koyama-Nasu Ryo, Latres Esther, Bronson Roderick, Yamasaki Lili, Pagano Michele

Abstract excerpt

The F-box protein betaTrcp1 controls the stability of several crucial regulators of proliferation and apoptosis, including certain inhibitors of the NF-kappaB family of transcription factors. Here we show that mammary glands of betaTrcp1(-/-) female mice display a hypoplastic phenotype, whereas no effects on cell proliferation are observed in other somatic cells. To investigate further the role of betaTrcp1 in...

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Identifiers

PMID: 15340078
DOI: 10.1128/MCB.24.18.8184-8194.2004
PMCID: PMC515055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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