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Article

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion.

Genes & development - 1 Mar 2010

Kanarek Naama, Horwitz Elad, Mayan Inbal, Leshets Michael, Cojocaru Gady, Davis Matti, Tsuberi Ben-Zion, Pikarsky Eli, Pagano Michele, Ben-Neriah Yinon

Abstract excerpt

beta-TrCP, the substrate recognition subunit of a Skp1-Cul1-F-box (SCF) ubiquitin ligase, is ubiquitously expressed from two distinct paralogs, targeting many regulatory proteins for proteasomal degradation. We generated inducible beta-TrCP hypomorphic mice and found that they are surprisingly healthy, yet have a severe testicular defect. We show that the two beta-TrCP paralogs have a nonredundant role in...

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Identifiers

PMID: 20194439
DOI: 10.1101/gad.551610
PMCID: PMC2827842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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