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Alternative roles of ClpX and ClpP in <i>Staphylococcus aureus</i> stress tolerance and virulence

12 May 2003

Abstract excerpt

Clp proteolytic complexes are essential for virulence and for survival under stress conditions in several pathogenic bacteria. Recently, a study using signature-tagged mutagenesis identified the ClpX ATPase as also being required for virulence in Staphylococcus aureus. Presently, we have constructed deletion mutants removing either ClpX or the proteolytic subunit, ClpP, in S. aureus 8325-4 in order to examine a...

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PMID: 12791139
DOI: 10.1046/j.1365-2958.2003.03524.x

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