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Article

Trapping and Proteomic Identification of Cellular Substrates of the ClpP Protease in <i>Staphylococcus aureus</i>

19 Dec 2012

Abstract excerpt

In the important human pathogen Staphylococcus aureus the cytoplasmic ClpP protease is essential for mounting cellular stress responses and for virulence. To directly identify substrates of the ClpP protease, we expressed in vivo a proteolytic inactive form of ClpP (ClpP(trap)) that will retain but not degrade substrates translocated into its proteolytic chamber. Substrates captured inside the proteolytic barrel...

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PMID: 23253041
DOI: 10.1021/pr300394r

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