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The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus

11 Sept 2017

Abstract excerpt

Abstract In living cells intracellular proteolysis is crucial for protein homeostasis, and ClpP proteases are conserved between eubacteria and the organelles of eukaryotic cells. In Staphylococcus aureus , ClpP associates to the substrate specificity factors, ClpX and ClpC forming two ClpP proteases, ClpXP and ClpCP. To address how individual ClpP proteases impact cell physiology, we constructed a S. aureus...

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PMID: 28924169
DOI: 10.1038/s41598-017-12122-y

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