Follicular Lymphoma Cell Lines, an <i>In Vitro</i> Model for Antigenic Selection and Cytokine‐Mediated Growth Regulation of Germinal Centre B Cells

Abstract excerpt

In the periphery, B cells differentiate in germinal centres (GCs) of secondary lymphoid organs. Isolated GC cells die quickly in vitro by apoptosis. Therefore, cell lines originating from follicular lymphomas, which are the malignant counterparts of GC B cells, would provide a stable in vitro model to study the immunobiology of GC B cells. We have established three novel human follicular lymphoma cell lines that...

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