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Article

Rescue of “crippled” germinal center B cells from apoptosis by Epstein-Barr virus

3 Aug 2005

Abstract excerpt

Epstein-Barr virus (EBV) is associated with B-cell lymphomas such as Hodgkin lymphoma, Burkitt lymphoma, and post-transplantation lymphoma, which originate from clonal germinal center (GC) B cells. During the process of somatic hypermutation, GC B cells can acquire deleterious or nonsense mutations in the heavy and light immunoglobulin genes. Such mutations abrogate the cell surface expression of the B-cell...

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Identifiers

PMID: 16076866
DOI: 10.1182/blood-2005-06-2341

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