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Article

Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis?

28 Mar 2014

Abstract excerpt

Follicular lymphoma (FL) is a B-cell neoplasm resulting from the transformation of germinal center (GC) B cells. Although t(14;18) and ectopic B-cell lymphoma 2 (BCL2) expression constitute the genetic hallmark of FL, t(14;18)(pos) B cells bearing genotypic and phenotypic features of FL cells can be found in the blood of most healthy individuals. Nevertheless, the localization of these FL-like cells (FLLCs) in...

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PMID: 24677543
DOI: 10.1182/blood-2013-12-545954

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