Article
Transcriptional analysis of the B cell germinal center reaction.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Klein Ulf, Tu Yuhai, Stolovitzky Gustavo A, Keller Jeffrey L, Haddad Joseph, Miljkovic Vladan, Cattoretti Giorgio, Califano Andrea, Dalla-Favera Riccardo
Abstract excerpt
The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that occur in B cells during GC transit (naive B cells --> centroblasts --> centrocytes --> memory B cells) by gene expression profiling. Naive B cells, characterized by the expression of cell cycle-inhibitory and antiapoptotic genes, become...
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