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Article

Microtubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity

12 Oct 2011

Abstract excerpt

CLIP-170 is a microtubule-binding protein and participates in diverse microtubule-associated cellular activities by regulating microtubule dynamics. Here we provide evidence that CLIP-170 is a mediator of the sensitivity of the anti-microtubule drug paclitaxel in breast cancer. In vitro cell proliferation assays reveal that CLIP-170 expression in breast cancer cell lines correlates with their sensitivity to...

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PMID: 21989536
DOI: 10.1002/path.3026

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