Article
Cytokine response to endotoxin in individuals heterozygous for the Delta32 mutation of chemokine receptor CCR5.
Cytokine - 21 Feb 2003
Heesen Michael, Schippers Emile F, Bloemeke Brunhilde, Kunz Dagmar, van Dissel Jaap T
Abstract excerpt
Studies of mice with a targeted disruption of the CCR5 gene suggest that the CC chemokine receptor 5 (CCR5) is a determinant of the cytokine response to endotoxin. In humans, a naturally occurring mutation of the CCR5 gene is a 32-basepair (bp) deletion which precludes the translation of the gene into a functional transmembrane protein. To evaluate the cytokine phenotype of heterozygosity for the 32 deletion, we...
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