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Article

The effect of the CCR5-delta32 deletion on global gene expression considering immune response and inflammation

1 Jan 2011

Abstract excerpt

BACKGROUND: The natural function of the C-C chemokine receptor type 5 (CCR5) is poorly understood. A 32 base pair deletion in the CCR5 gene (CCR5-delta32) located on chromosome 3 results in a non-functional protein. It is supposed that this deletion causes an alteration in T-cell response to inflammation. For example, the presence of the CCR5-delta32 allele in recipients of allografts constitutes as an...

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PMID: 22029606
DOI: 10.1186/1476-9255-8-29

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