Article
The CCR5Δ32 polymorphism in Brazilian patients with sickle cell disease.
Disease markers - 1 Jan 2014
Lopes Mariana Pezzute, Santos Magnun Nueldo Nunes, Faber Eliel Wagner, Bezerra Marcos André Cavalcanti, Hatzlhofer Betânia Lucena Domingues, Albuquerque Dulcinéia Martins, Zaccariotto Tânia Regina, Ribeiro Daniela Maria, Araújo Aderson da Silva, Costa Fernando Ferreira, Sonati Maria de Fátima
Abstract excerpt
BACKGROUND: Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less efficient Th1 response. We determined the frequency of the CCR5Δ32 polymorphism in 795...
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