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Article

An assessment of a multiplex PCR assay for differentiating clinically important mycobacteria based on pncA gene variation.

Molecular and cellular probes - 1 Jan 2000

Bamaga Mohammad S, Wright David J, Zhang Hongyi

Abstract excerpt

The pncA genes in mycobacteria are responsible for the production of pyrazinamidase (PZase). In Mycobacterium tuberculosis, PZase hydrolyses pyrazinamide (PZA) to pyrazonic acid, a compound that possesses bactericidal activity against tubercle bacilli. Nucleotide sequences of pncA genes found within mycobacteria where aligned in an effort to ascertain the significance of any variability in sequence. Three sets of...

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PMID: 12788027
DOI: 10.1016/s0890-8508(03)00004-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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