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Article

pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal.

Antimicrobial agents and chemotherapy - 1 Jul 2004

Portugal Isabel, Barreiro Luís, Moniz-Pereira José, Brum Laura

Abstract excerpt

The nucleotide sequences of the pncA genes within 55 multidrug-resistant pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates were determined. Fifty-three out of the 55 isolates were pyrazinamidase (PZase) negative. Four strains contained a wild-type pncA gene, and PZase activity was undetectable in two of these strains. Seven of the 18 identified pncA mutations found have not been described in...

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Identifiers

PMID: 15215139
DOI: 10.1128/AAC.48.7.2736-2738.2004
PMCID: PMC434191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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