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Article

Association between pncA gene mutations, pyrazinamidase activity, and pyrazinamide susceptibility testing in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Aug 2014

Aono Akio, Chikamatsu Kinuyo, Yamada Hiroyuki, Kato Tomoko, Mitarai Satoshi

Abstract excerpt

We determined MICs for, confirmed the presence of pncA mutations in, and performed pyrazinamidase testing on colonies (subclones) obtained from seven isolates that exhibited differential pyrazinamide (PZA) susceptibility. Six of the seven strains were found to exhibit characteristics resulting from the mixture of strains possessing different properties. In addition, our analysis revealed large pncA-spanning...

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Identifiers

PMID: 24867972
DOI: 10.1128/AAC.02394-14
PMCID: PMC4136016

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