Article
Six1 is required for the early organogenesis of mammalian kidney.
Development (Cambridge, England) - 1 Jul 2003
Xu Pin-Xian, Zheng Weiming, Huang Li, Maire Pascal, Laclef Christine, Silvius Derek
Abstract excerpt
The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is composed of six members (Six1-6). Among the six members, only the Six2 gene has been previously shown to be expressed early in kidney development, but its function is unknown. We have recently found that the Six1 gene is also expressed in the kidney. In the developing kidney, Six1 is...
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