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Article

SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation

29 Jan 2010

Abstract excerpt

Dysfunction of the ureter often leads to urine flow impairment from the kidney to the bladder, causing dilation of the ureter and/or renal pelvis. Six1 is a crucial regulator of renal development: mutations in human SIX1 cause branchio-oto-renal (BOR) syndrome and Six1(-/-) mice exhibit renal agenesis, although the ureter is present. It remains unclear whether Six1 plays a role in regulating ureter morphogenesis....

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Identifiers

PMID: 20110314
DOI: 10.1242/dev.045757

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SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formationPMID 20110314Read ↗

Six1 is required for the early organogenesis of mammalian kidney.Semantic proximity Read ↗

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defectsSemantic proximity Read ↗

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.Semantic proximity Read ↗

Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice.Semantic proximity Read ↗

Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.Semantic proximity Read ↗

SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation.Semantic proximity Read ↗

Mutations in SIX1 associated with Branchio-oto-renal Syndrome (BOR) differentially affect otic expression of putative target genesSemantic proximity Read ↗

Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development.Semantic proximity Read ↗

ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenanceSemantic proximity Read ↗

Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial DevelopmentSemantic proximity Read ↗

Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial developmentSemantic proximity Read ↗

Sobp modulates Six1 transcriptional activation and is required during craniofacial developmentSemantic proximity Read ↗

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