Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hox11 paralogous genes are essential for metanephric kidney induction.

Genes & development - 1 Jun 2002

Wellik Deneen M, Hawkes Patrick J, Capecchi Mario R

Abstract excerpt

The mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phenotypes which are difficult to interpret by molecular analysis. For example, mice individually mutant for Hoxa11 or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Homeodomain Proteins
Share to In Situ Nick-End Labeling
Share to Kidney

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

Share to Oncogene Proteins

Share to PAX2 Transcription Factor

Share to Ureter

Share to WT1 Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12050119
DOI: 10.1101/gad.993302
PMCID: PMC186320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hox11 paralogous genes are essential for metanephric kidney induction.PMID 12050119Read ↗

Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.Semantic proximity Read ↗

Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney.Semantic proximity Read ↗

Six1 is required for the early organogenesis of mammalian kidney.Semantic proximity Read ↗

Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme.Semantic proximity Read ↗

Genetic determination of nephrogenesis: the Pax/Eya/Six gene networkSemantic proximity Read ↗

Hox genes and kidney patterning.Semantic proximity Read ↗

Comprehensive microarray analysis of Hoxa11/Hoxd11 mutant kidney development.Semantic proximity Read ↗

Distinct roles and regulations for HoxD genes in metanephric kidney development.Semantic proximity Read ↗

Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extensionSemantic proximity Read ↗

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defectsSemantic proximity Read ↗

Notch2 Activation in the Embryonic Kidney Depletes Nephron ProgenitorsSemantic proximity Read ↗

Functional specificity of the Hoxa13 homeobox.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.