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Article

Sequential gene targeting to make chimeric tumor models with de novo chromosomal abnormalities.

Cancer research - 1 Mar 2014

Chambers Jennifer S, Tanaka Tomoyuki, Brend Tim, Ali Hanif, Geisler Nicola J, Khazin Leah, Cigudosa Juan C, Dear T Neil, MacLennan Kenneth, Rabbitts Terence H

Abstract excerpt

The discovery of chromosomal translocations in leukemia/lymphoma and sarcomas presaged a widespread discovery in epithelial tumors. With the advent of new-generation whole-genome sequencing, many consistent chromosomal abnormalities have been described together with putative driver and passenger mutations. The multiple genetic changes required in mouse models to assess the interrelationship of abnormalities and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24419086
DOI: 10.1158/0008-5472.CAN-13-1783

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