Article
Association of CYP17 genetic polymorphism with intra-tumoral estradiol concentrations but not with CYP17 messenger RNA levels in breast cancer tissue.
Cancer letters - 30 May 2003
Miyoshi Yasuo, Ando Akiko, Ooka Masaru, Shiba Eiichi, Taguchi Tetsuya, Tamaki Yasuhiro, Noguchi Shinzaburo
Abstract excerpt
The variant allele(1931C) of CYP17 (1931C/T), which is one of the key enzymes involved in estrogens synthesis, has been shown to be associated with breast cancer risk. Since this variant allele creates an additional putative Sp-1 binding site (CCACC) in the promoter region, it is speculated that it enhances the transcription of CYP17, leading to the enhanced estrogens synthesis in breast tumors. CYP17 messenger...
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