Article
Association between CYP17 gene polymorphism and risk of breast cancer in young women.
International journal of cancer - 20 Aug 1999
Bergman-Jungeström M, Gentile M, Lundin A C, Wingren S
Abstract excerpt
Long-term exposure to oestrogens is a well-recognised risk factor for breast cancer, whereas little is known about the influence of polymorphisms of genes involved in oestrogen biosynthesis and metabolism. A candidate, containing a single bp polymorphism, T-->C, (designated, A2 allele), might be the CYP17 gene, which codes for an enzyme involved in oestrogen synthesis. This polymorphism creates an additional...
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