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Article

Association of a CYP17 gene polymorphism with development of breast cancer in India.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2010

Surekha D, Sailaja K, Rao D Nageswara, Padma T, Raghunadharao D, Vishnupriya S

Abstract excerpt

The human CYP17 gene, located on chromosome 10q24.3, plays a key role in sex steroid synthesis, mainly related to estrogen. A 5' UTR polymorphism involving a single base pair change in the promoter region results in increased transcriptional activity. In the present study of 250 breast cancer cases and 250 ma tched controls, the A1 genotype frequency was elevated in the disease group, while the A2 genotype...

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PMID: 21338212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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