Article
Novel anterior segment phenotypes resulting from forkhead gene alterations: evidence for cross-species conservation of function.
Investigative ophthalmology & visual science - 1 Jun 2003
Lehmann Ordan J, Tuft Stephen, Brice Glen, Smith Richard, Blixt Asa, Bell Rachel, Johansson Bengt, Jordan Tim, Hitchings Roger A, Khaw Peng T, John Simon W M, Carlsson Peter, Bhattacharya Shomi S
Abstract excerpt
PURPOSE: Mutations in murine and human versions of an ancestrally related gene usually result in similar phenotypes. However, interspecies differences exist, and in the case of two forkhead transcription factor genes (FOXC1 and FOXC2), these differences include corneal or anterior segment phenotypes, respectively. This study was undertaken to determine whether such discrepancies provide an opportunity for...
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