Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced human and murine corneal thickness in an Axenfeld-Rieger syndrome subtype.

Investigative ophthalmology & visual science - 1 Nov 2006

Asai-Coakwell Mika, Backhouse Christopher, Casey Ronald J, Gage Philip J, Lehmann Ordan J

Abstract excerpt

PURPOSE: Axenfeld-Rieger malformations of the anterior segment are clinically heterogeneous, and up to 50% of cases are attributable to PITX2 or FOXC1 mutation. In view of PITX2's contribution to corneal development and the altered CCT in some FOXC1-related cases, this study was undertaken to investigate whether a related phenotype is associated with the PITX2/Pitx2 mutation. METHODS: Central corneal thickness...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weights and Measures
Share to Cornea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Abnormalities

Share to Glaucoma

Share to Homeobox Protein PITX2

Share to Microscopy, Electron, Scanning

Share to Tomography, Optical Coherence

Share to Ultrasonography

Source

Identifiers

PMID: 17065505
DOI: 10.1167/iovs.06-0457

Genes

PITX2
FOXC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced human and murine corneal thickness in an Axenfeld-Rieger syndrome subtype.PMID 17065505Read ↗

Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants.Semantic proximity Read ↗

Glaucoma spectrum and age-related prevalence of individuals with FOXC1 and PITX2 variantsSemantic proximity Read ↗

PITX2 deficiency and associated human disease: insights from the zebrafish model.Semantic proximity Read ↗

Pitx2-associated early-onset glaucoma alters corneal innervation and sensory function in a sex-specific mannerSemantic proximity Read ↗

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.Semantic proximity Read ↗

Genomic Locus Modulating Corneal Thickness in the Mouse Identifies <i>POU6F2</i> as a Potential Risk of Developing GlaucomaSemantic proximity Read ↗

pitx2 Deficiency results in abnormal ocular and craniofacial development in zebrafish.Semantic proximity Read ↗

PITX2 gain-of-function in Rieger syndrome eye model.Semantic proximity Read ↗

Molecular genetics of Axenfeld-Rieger malformationsSemantic proximity Read ↗

Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations.Semantic proximity Read ↗

Genetic Dependence of Central Corneal Thickness among Inbred Strains of MiceSemantic proximity Read ↗

Corneal Plana-Like Phenotype With Peripheral Scleralization Associated With a Pathogenic Variant of PITX2 : A Case Report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.