Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Foxe3 haploinsufficiency in mice: a model for Peters' anomaly.

Investigative ophthalmology & visual science - 1 May 2002

Ormestad Mattias, Blixt Asa, Churchill Amanda, Martinsson Tommy, Enerbäck Sven, Carlsson Peter

Abstract excerpt

PURPOSE: To evaluate the importance in anterior segment dysgenesis of genetic variation in Foxe3, a gene encoding a forkhead transcription factor specifically expressed in the lens. METHODS: The phenotype of mice heterozygous for a mutation in the DNA-binding domain of Foxe3 was examined from histologic sections, and DNA binding by the encoded protein was investigated by gel-shift assay. FOXE3 from human patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anterior Eye Segment
Share to Cataract
Share to Corneal Opacity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Abnormalities

Share to Forkhead Transcription Factors

Share to Mice, Inbred BALB C

Share to Mice, Mutant Strains

Share to Radiation Hybrid Mapping

Source

Identifiers

PMID: 11980846

Genes

FOXE3
PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Foxe3 haploinsufficiency in mice: a model for Peters' anomaly.PMID 11980846Read ↗

Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts.Semantic proximity Read ↗

Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.Semantic proximity Read ↗

Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies.Semantic proximity Read ↗

Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation.Semantic proximity Read ↗

Insights Into the FOXE3 Transcriptional Network and Disease Mechanisms From the Investigation of a Regulatory Variant Driving Complex Microphthalmia.Semantic proximity Read ↗

Insights into the FOXE3 Transcriptional Network and Disease Mechanisms from the Investigation of a Regulatory Variant Driving Complex MicrophthalmiaSemantic proximity Read ↗

A novel, non-stop mutation in FOXE3 causes an autosomal dominant form of variable anterior segment dysgenesis including Peters anomaly.Semantic proximity Read ↗

Comprehensive phenotypic and functional analysis of dominant and recessive FOXE3 alleles in ocular developmental disorders.Semantic proximity Read ↗

A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans.Semantic proximity Read ↗

Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.Semantic proximity Read ↗

FOXE3 plays a significant role in autosomal recessive microphthalmia.Semantic proximity Read ↗

A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.