Article
Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994
Dietrich W F, Radany E H, Smith J S, Bishop J M, Hanahan D, Lander E S
Abstract excerpt
A genome-wide scan for loss of heterozygosity (LOH) in tumors provides a powerful route to the identification of genes involved in tumorigenesis. This approach has not previously been applied to transgenic mice, despite the considerable advantages they afford for genetic dissection. Here, we report a genome-wide LOH analysis of insulinomas and carcinoid tumors in transgenic mice expressing the simian virus 40...
Topics
- Alleles
- Animals
- Carcinoid Tumor
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 6
- DNA, Neoplasm
- Genes, Tumor Suppressor