Article
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine - 1 Jan 2011
Ermakova Olga, Piszczek Lukasz, Luciani Luisa, Cavalli Florence M G, Ferreira Tiago, Farley Dominika, Rizzo Stefania, Paolicelli Rosa Chiara, Al-Banchaabouchi Mumna, Nerlov Claus, Moriggl Richard, Luscombe Nicholas M, Gross Cornelius
Abstract excerpt
The identification of susceptibility genes for human disease is a major goal of current biomedical research. Both sequence and structural variation have emerged as major genetic sources of phenotypic variability and growing evidence points to copy number variation as a particularly important source of susceptibility for disease. Here we propose and validate a strategy to identify genes in which changes in dosage...
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