Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit.

Article

Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 1998

Traynelis S F, Burgess M F, Zheng F, Lyuboslavsky P, Powers J L

Abstract excerpt

Zinc inhibits NMDA receptor function through both voltage-dependent and voltage-independent mechanisms. In this report we have investigated the role that the NR1 subunit plays in voltage-independent Zn2+ inhibition. Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 fo...

Topics

Animals
DNA, Recombinant
Electrophysiology
Exons
Female
Mutation
Oocytes
Polyamines
Protons
Receptors, N-Methyl-D-Aspartate
Spermine
Xenopus laevis
Zinc

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