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Article

Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 1998

Traynelis S F, Burgess M F, Zheng F, Lyuboslavsky P, Powers J L

Abstract excerpt

Zinc inhibits NMDA receptor function through both voltage-dependent and voltage-independent mechanisms. In this report we have investigated the role that the NR1 subunit plays in voltage-independent Zn2+ inhibition. Our data show that inclusion of exon 5 into the NR1 subunit increases the IC50 for voltage-independent Zn2+ inhibition from 3-fold to 10-fold when full length exon 22 is also spliced into the mature...

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PMID: 9698310
PMCID: PMC6793196

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