Article

A conserved glycine harboring disease-associated mutations is required for slow deactivation and high Ca <sup>2+</sup> permeability in NMDA receptors

2018-05-03

Abstract excerpt

<h4>ABSTRACT</h4> A variety of de novo and inherited missense mutations associated with neurological disorders are found in the NMDA receptor M4 transmembrane helices, which are peripheral to the pore domain in eukaryotic ionotropic glutamate receptors. Subsets of these mutations affect receptor gating with dramatic effects, including in one instance halting it, occurring at a conserved glycine near the extracel...

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Literature Corpus work: 470e6fe1-f7e7-5d81-8f5e-a3cbae0476da
DOI: 10.1101/313452

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