Article
Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.
The Journal of physiology - 1 Jan 1998
Wollmuth L P, Kuner T, Sakmann B
Abstract excerpt
1. The voltage-dependent block of N-methyl-D-aspartate (NMDA) receptor channels by extracellular Mg2+ is a critical determinant of its contribution to CNS synaptic physiology. The function of the narrow constriction of the channel in determining the block was investigated by analysing the effects...
Topics
- Amino Acid Sequence
- Animals
- Asparagine
- Cell Line
- Electrophysiology
- Extracellular Space
- Glycine
- Humans
- Ion Channel Gating
- Magnesium
- Molecular Sequence Data
- Mutation
- Oocytes
- Receptors, N-Methyl-D-Aspartate
- Xenopus