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Article

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.

The Journal of physiology - 1 Jan 1998

Wollmuth L P, Kuner T, Sakmann B

Abstract excerpt

1. The voltage-dependent block of N-methyl-D-aspartate (NMDA) receptor channels by extracellular Mg2+ is a critical determinant of its contribution to CNS synaptic physiology. The function of the narrow constriction of the channel in determining the block was investigated by analysing the effects of a set different amino acid substitutions at exposed residues positioned at or near this region. NMDA receptor...

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Identifiers

PMID: 9481670
DOI: 10.1111/j.1469-7793.1998.013bx.x
PMCID: PMC2230696

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Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.PMID 9481670Read ↗

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