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Article

Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.

Journal of neurochemistry - 1 Dec 2024

Song Rui, Zhang Jin, Perszyk Riley E, Camp Chad R, Tang Weiting, Kannan Varun, Li Jia, Xu Yuchen, Chen Jiahui, Li Yinlong, Liang Steven H, Traynelis Stephen F, Yuan Hongjie

Abstract excerpt

N-methyl-D-aspartate receptors (NMDAR), ionotropic glutamate receptors, mediate a slow component of excitatory synaptic transmission in the central nervous system and play a key role in normal brain function and development. Genetic variations in GRIN genes encoding NMDAR subunits that alter the receptor's functional characteristics are associated with a wide range of neurological and neuropsychiatric conditions....

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Source

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Identifiers

PMID: 37649269
DOI: 10.1111/jnc.15942
PMCID: PMC10902181

Genes

GRIN1
GRIN2A
GRIN2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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