Article
Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.
Molecular pharmacology - 1 Feb 1995
Wafford K A, Kathoria M, Bain C J, Marshall G, Le Bourdellès B, Kemp J A, Whiting P J
Abstract excerpt
The mammalian N-methyl-D-aspartate (NMDA) receptor complex is though to consist of an NR1 subunit in combination with one or more of the four NR2 subunits (A, B, C, and D). When corresponding cDNAs are expressed in Xenopus oocytes, ion channels with the characteristic profile of NMDA receptors are formed. The receptor is unique in requiring two coagonists, glutamate and glycine, for activation of the channel. We...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Binding Sites
- Glycine
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, N-Methyl-D-Aspartate
- Sequence Homology, Amino Acid
- Xenopus