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Article

Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

Cell death and differentiation - 1 May 2003

Ozaki M, Haga S, Zhang H Q, Irani K, Suzuki S

Abstract excerpt

Rac1-regulated reactive oxygen species (ROS) production has been implicated in apoptosis. In contrast, pleiotropic protein kinase Akt protects against apoptosis. However, the pro- and antiapoptotic mechanisms of rac1 and Akt, respectively, and the intersection between these mechanisms are incompl...

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Source

Identifiers

PMID: 12728249
DOI: 10.1038/sj.cdd.4401172

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12728249-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.PMID 12728249Read ↗

Hepatocyte Growth Factor Protects Endothelial Barrier Against Oxidative Stress and Mitochondria-dependent ApoptosisSemantic proximity Read ↗

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Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.Semantic proximity Read ↗

β1-Integrin is up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response.Semantic proximity Read ↗

The Heme Oxygenase-1 Protein Is Overexpressed in Human Renal Cancer Cells following Activation of the Ras-Raf-ERK Pathway and Mediates Anti-Apoptotic SignalSemantic proximity Read ↗

TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis.Semantic proximity Read ↗

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.Semantic proximity Read ↗

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.Semantic proximity Read ↗

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.Semantic proximity Read ↗

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Inactivation of the small GTPase Rac1 protects the liver from ischemia/reperfusion injury in the rat.Semantic proximity Read ↗

Telomere length and reactive oxygen species levels are positively associated with a high risk of mortality and recurrence in hepatocellular carcinomaSemantic proximity Read ↗

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