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Article

Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis.

The Journal of biological chemistry - 26 Mar 2010

Li Qian, Li Geng, Lan Xiaomei, Zheng Ming, Chen Kuang-Hueih, Cao Chun-Mei, Xiao Rui-Ping

Abstract excerpt

Proliferation of vascular smooth muscle cells (VSMCs) is a primary mechanism underlying cardiovascular proliferative disorders. Phosphoinositide 3-kinase (PI3K)-Akt (or protein kinase B) axis has been assigned at the center of pathways that regulate cell proliferation. Here we demonstrate that enhanced PI3K-Akt signaling by mitogenic stimulation or arterial injury profoundly elevates expression of receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Share to Proto-Oncogene Proteins c-akt

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Share to Receptor-Interacting Protein Serine-Threonine Kinases

Source

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Identifiers

PMID: 20042608
DOI: 10.1074/jbc.M109.071332
PMCID: PMC2843204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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