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Article

Structure/function analysis of an RNA aptamer for hepatitis C virus NS3 protease.

Journal of biochemistry - 1 Mar 2003

Sekiya Satoru, Nishikawa Fumiko, Fukuda Kotaro, Nishikawa Satoshi

Abstract excerpt

RNA aptamers that bind specifically to hepatitis C virus (HCV) NS3 protease domain (DeltaNS3) were identified in previous studies. These aptamers, G9-I, -II, and -III, were isolated using an in vitro selection method and they share a common loop with the sequence 5'-GA(A/U)UGGGAC-3'. The aptamers are potent inhibitors of the NS3 protease in vitro and may have potential as anti-HCV compounds. G9-I has a 3-way...

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Identifiers

PMID: 12761171
DOI: 10.1093/jb/mvg047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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