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Article

Structure and function analysis of the essential 3'X domain of hepatitis C virus.

RNA (New York, N.Y.) - 1 Feb 2020

Castillo-Martínez Jesús, Ovejero Tamara, Romero-López Cristina, Sanmartín Isaías, Berzal-Herranz Beatriz, Oltra Elisa, Berzal-Herranz Alfredo, Gallego José

Abstract excerpt

The 3'X domain of hepatitis C virus has been reported to control viral replication and translation by modulating the exposure of a nucleotide segment involved in a distal base-pairing interaction with an upstream 5BSL3.2 domain. To study the mechanism of this molecular switch, we have analyzed the structure of 3'X mutants that favor one of the two previously proposed conformations comprising either two or three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31694875
DOI: 10.1261/rna.073189.119
PMCID: PMC6961542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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